v9.6.5 (Database Updated 06/06/2024)

Database updated on 06/06/2024 with 437 changes
Gene Annotation Version 6.57
Anatomy Ontology Version 2024-04-25

Welcome to REDfly
Regulatory Element Database for Drosophila and other insects v9.6.5
REDfly version 9.6.5 released!
The REDfly source code now available in GitHub!

The REDfly team respects the diversity of all individuals, regardless of race,
ethnicity, sex, disability, religion, gender identification, or sexual orientation.

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Thank you for visiting REDfly! We are hard at work bringing you new features and a better user experience. We want to hear where you want to see us go!
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REDfly is a curated collection of known insect transcriptional cis-regulatory modules (CRMs), cis-regulatory module segments (CRMsegs), predicted cis-regulatory modules (pCRMs), and transcription factor binding sites (TFBSs). Our mission is to extract, accumulate, organize, annotate, and link the growing body of information on insect transcriptional cis-regulatory sequences, with an emphasis on empirically validated CRMs curated from the published literature. The majority of the data are for Drosophila melanogaster, but we also annotate an increasing number of other insects. Despite more than 20 years of experimental determination of these elements, the data have never been collected into a single searchable database. REDfly seeks to include all experimentally verified fly regulatory elements along with their DNA sequence, their associated genes, and the expression patterns they direct. Expression patterns are annotated using a defined anatomy ontology to enable high interoperability with FlyBase, FlyExpress, the BDGP in situ hybridization database, and other model organism resources.

If you know of experimentally verified cis-regulatory elements that are not included in the REDfly database, or have corrections to the archived data, please contact us.

REDfly has 58034 CRMs (17100 from in vivo reporter genes, 40586 from cell-culture assays, and 349 from other evidence) associated with 2030 genes, 42 CRMsegs associated with 23 genes, 14318 pCRMs, and 2806 TFBSs bound by 216 transcription factors acting on 329 target genes. These data are based on 1497 curated publications.

The regulatory data curated by REDfly are the result of the hard work of members of the research community. When using specific CRM, CRMseg, pCRM, and TFBS data, please make sure to cite the original discoverers.

Funded in part by the NSF and the NIGMS

Copyright © University at Buffalo—State University of New York. REDfly is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. See License.
The copyrights of all curated content belong to their respective owners.